[HTML][HTML] Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers

L Peng, ZR Li, RS Green, IR Holzmanr, J Lin - The Journal of nutrition, 2009 - Elsevier
Butyrate, one of the SCFA, promotes the development of the intestinal barrier. However, the
molecular mechanisms underlying the butyrate regulation of the intestinal barrier are
unknown. To test the hypothesis that the effect of butyrate on the intestinal barrier is
mediated by the regulation of the assembly of tight junctions involving the activation of the
AMP-activated protein kinase (AMPK), we determined the effect of butyrate on the intestinal
barrier by measuring the transepithelial electrical resistance (TER) and inulin permeability in …