[HTML][HTML] Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization …
DA Bloom, AK Jaiswal - Journal of Biological Chemistry, 2003 - ASBMB
The antioxidant response element (ARE) and transcription factor Nrf2 regulate basal
expression and antioxidant induction of NAD (P) H: quinone oxidoreductase-1 (NQO1) and
other detoxifying genes. Under normal conditions, Nrf2 is targeted for proteasomal
degradation by INrf2. Oxidative stress causes release of Nrf2 from INrf2. Nrf2 translocates to
the nucleus, binds to the ARE, and activates gene expression. In this study, we demonstrate
that protein kinase C (PKC) plays a significant role in the regulation of ARE-mediated NQO1 …
expression and antioxidant induction of NAD (P) H: quinone oxidoreductase-1 (NQO1) and
other detoxifying genes. Under normal conditions, Nrf2 is targeted for proteasomal
degradation by INrf2. Oxidative stress causes release of Nrf2 from INrf2. Nrf2 translocates to
the nucleus, binds to the ARE, and activates gene expression. In this study, we demonstrate
that protein kinase C (PKC) plays a significant role in the regulation of ARE-mediated NQO1 …