During the last decade, advances in sequencing technologies allowed production of a
wealth of information on epigenetic modifications in T cells. Epigenome maps, in
combination with mechanistic studies, have demonstrated that T cells undergo extensive
epigenome remodeling in response to signals, which has a strong effect on phenotypic
stability and function of lymphocytes. In this review we focus on DNA methylation, histone
modifications, and chromatin structure as important epigenetic mechanisms involved in …