[HTML][HTML] Role of oligosaccharide residues of IgG1-Fc in FcγRIIb binding
Y Mimura, P Sondermann, R Ghirlando, J Lund… - Journal of Biological …, 2001 - ASBMB
Engagement of Fcγ receptors (FcγRs) with the Fc region of IgG elicits immune responses by
leukocytes. The recent crystal structure of FcγRIII in complex with IgG-Fc has provided
details of molecular interactions between these components (Sondermann, P., Huber, R.,
Oosthuizen, V., and Jacob, U.(2000) Nature406, 267–273). One of the most intriguing issues
is that glycosylation of IgG-Fc is essential for the recognition by FcγRs although the
carbohydrate moieties are on the periphery of the FcγRIII-Fc interface. To better understand …
leukocytes. The recent crystal structure of FcγRIII in complex with IgG-Fc has provided
details of molecular interactions between these components (Sondermann, P., Huber, R.,
Oosthuizen, V., and Jacob, U.(2000) Nature406, 267–273). One of the most intriguing issues
is that glycosylation of IgG-Fc is essential for the recognition by FcγRs although the
carbohydrate moieties are on the periphery of the FcγRIII-Fc interface. To better understand …