Spontaneously arising cytotoxicity to the P-815-Y mastocytoma in NZB mice.

AH Greenberg, JH Playfair - Clinical and experimental immunology, 1974 - ncbi.nlm.nih.gov
AH Greenberg, JH Playfair
Clinical and experimental immunology, 1974ncbi.nlm.nih.gov
SUMMARY A spontaneously arising cytotoxic lymphoid cellin NZB mice is described. The
cells, which appeared at about 9 months of age, were capable of killing the P-815-Y mas-
tocytoma, but not a methylcholanthrene-induced sarcoma or chicken erythrocytes.
Fractionation of NZB spleen cells indicated that the effector cell was neither phagocytic nor
of T-cell origin. Antibody-dependent cytotoxicity in the NZB was then examined and found to
be reduced when compared to the BALB/c. The role of this cell in the spontaneous …
SUMMARY A spontaneously arising cytotoxic lymphoid cellin NZB mice is described. The cells, which appeared at about 9 months of age, were capable of killing the P-815-Y mas-tocytoma, but not a methylcholanthrene-induced sarcoma or chicken erythrocytes. Fractionation of NZB spleen cells indicated that the effector cell was neither phagocytic nor of T-cell origin. Antibody-dependent cytotoxicity in the NZB was then examined and found to be reduced when compared to the BALB/c. The role of this cell in the spontaneous cytotoxicity of the P-815-Y and its potential significance in the pathogenesis of autoimmune disease is discussed.
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