Treatment of patients with advanced cancer with the natural killer cell line NK-92
T Tonn, D Schwabe, HG Klingemann, S Becker… - Cytotherapy, 2013 - Elsevier
Background aims Natural killer (NK) cells, either naive or genetically engineered, are
increasingly considered for cellular therapy of patients with malignancies. When using NK
cells from peripheral blood, the number of expanded NK cells can be highly variable and the
need for NK cell enrichment can make the process expensive. The NK-92 cell line
(CD56+/CD3−) that was isolated from a patient with lymphoma has predictable high
cytotoxic activity and can be expanded under good manufacturing practice conditions in …
increasingly considered for cellular therapy of patients with malignancies. When using NK
cells from peripheral blood, the number of expanded NK cells can be highly variable and the
need for NK cell enrichment can make the process expensive. The NK-92 cell line
(CD56+/CD3−) that was isolated from a patient with lymphoma has predictable high
cytotoxic activity and can be expanded under good manufacturing practice conditions in …