Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function
D Wang, VV Patel, E Ricciotti, R Zhou… - Proceedings of the …, 2009 - National Acad Sciences
Proceedings of the National Academy of Sciences, 2009•National Acad Sciences
Nonsteroidal anti-inflammatory drugs selective for inhibition of COX-2 increase heart failure
and elevate blood pressure. The COX-2 gene was floxed and crossed into merCremer mice
under the α-myosin heavy-chain promoter. Tamoxifen induced selective deletion of COX-2
in cardiomyocytes depressed cardiac output, and resulted in weight loss, diminished
exercise tolerance, and enhanced susceptibility to induced arrhythmogenesis. The cardiac
dysfunction subsequent to pressure overload recovered progressively in the knockouts …
and elevate blood pressure. The COX-2 gene was floxed and crossed into merCremer mice
under the α-myosin heavy-chain promoter. Tamoxifen induced selective deletion of COX-2
in cardiomyocytes depressed cardiac output, and resulted in weight loss, diminished
exercise tolerance, and enhanced susceptibility to induced arrhythmogenesis. The cardiac
dysfunction subsequent to pressure overload recovered progressively in the knockouts …
Nonsteroidal anti-inflammatory drugs selective for inhibition of COX-2 increase heart failure and elevate blood pressure. The COX-2 gene was floxed and crossed into merCremer mice under the α-myosin heavy-chain promoter. Tamoxifen induced selective deletion of COX-2 in cardiomyocytes depressed cardiac output, and resulted in weight loss, diminished exercise tolerance, and enhanced susceptibility to induced arrhythmogenesis. The cardiac dysfunction subsequent to pressure overload recovered progressively in the knockouts coincident with increasing cardiomyocyte hypertrophy and interstitial and perivascular fibrosis. Inhibition of COX-2 in cardiomyocytes may contribute to heart failure in patients receiving nonsteroidal anti-inflammatory drugs specific for inhibition of COX-2.
National Acad Sciences