[HTML][HTML] Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications
Endogenous damage-associated molecular patterns (DAMPs) are released during tissue
damage and have increasingly recognized roles in the etiology of many human diseases.
The inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD),
are immune-mediated conditions where high levels of DAMPs are observed. DAMPs such
as calprotectin (S100A8/9) have an established clinical role as a biomarker in IBD. In this
review, we use IBD as an archetypal common chronic inflammatory disease to focus on the …
damage and have increasingly recognized roles in the etiology of many human diseases.
The inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD),
are immune-mediated conditions where high levels of DAMPs are observed. DAMPs such
as calprotectin (S100A8/9) have an established clinical role as a biomarker in IBD. In this
review, we use IBD as an archetypal common chronic inflammatory disease to focus on the …