Lipoxin biosynthesis in inflammatory bowel disease

MJ Mangino, L Brounts, B Harms, C Heise - Prostaglandins & other lipid …, 2006 - Elsevier
BACKGROUND AND AIMS: Lipoxins are anti-inflammatory lipid mediators that are produced
in gut mucosa, which serve to limit and resolve persistent inflammation. The purpose of this
study was to evaluate colonic lipoxin biosynthesis in patients with ulcerative colitis (UC) to
establish a possible biochemical basis for persistent inflammation in UC. METHODS:
Colonic mucosa from patients with UC or organ donors (controls) was placed into tissue
culture for 90min. The conditioned media was assayed (ELISA) for lipoxin A4 (LXA) and the …