Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

AK Shukla, K Xiao, RJ Lefkowitz - Trends in biochemical sciences, 2011 - cell.com
Trends in biochemical sciences, 2011cell.com
β-Arrestins, originally discovered to desensitize activated seven transmembrane receptors
(7TMRs; also known as G-protein-coupled receptors, GPCRs), are now well established
mediators of receptor endocytosis, ubiquitylation and G protein-independent signaling.
Recent global analyses of β-arrestin interactions and β-arrestin-dependent phosphorylation
events have uncovered several previously unanticipated roles of β-arrestins in a range of
cellular signaling events. These findings strongly suggest that the functional roles of β …
β-Arrestins, originally discovered to desensitize activated seven transmembrane receptors (7TMRs; also known as G-protein-coupled receptors, GPCRs), are now well established mediators of receptor endocytosis, ubiquitylation and G protein-independent signaling. Recent global analyses of β-arrestin interactions and β-arrestin-dependent phosphorylation events have uncovered several previously unanticipated roles of β-arrestins in a range of cellular signaling events. These findings strongly suggest that the functional roles of β-arrestins are much broader than currently understood. Biophysical studies aimed at understanding multiple active conformations of the 7TMRs and the β-arrestins have begun to unravel the mechanistic basis for the diverse functional capabilities of β-arrestins in cellular signaling.
cell.com