TGF-β1 overexpression in murine pancreas induces chronic pancreatitis and together with TNF-α, triggers insulin-dependent diabetes
F Sanvito, A Nichols, PL Herrera, J Huarte… - Biochemical and …, 1995 - Elsevier
F Sanvito, A Nichols, PL Herrera, J Huarte, A Wohlwend, JD Vassalli, L Orci
Biochemical and biophysical research communications, 1995•ElsevierWe have generated transgenic mice overexpressing TGF-β1 in pancreatic β cells. This
resulted in massive fibrosis of the pancreas; in adult mice, most of the acini were replaced by
fibrotic and adipose tissues. A conspicuous disorganisation of the islets of Langerhans was
also observed, however, the number of β cells was not decreased and the mice were
normoglycemic. Backcrossing to transgenic mice overexpressing TNF-α in their islet β cells
(which also remain normoglycemic,(1)) yielded double transgenics, most of which became …
resulted in massive fibrosis of the pancreas; in adult mice, most of the acini were replaced by
fibrotic and adipose tissues. A conspicuous disorganisation of the islets of Langerhans was
also observed, however, the number of β cells was not decreased and the mice were
normoglycemic. Backcrossing to transgenic mice overexpressing TNF-α in their islet β cells
(which also remain normoglycemic,(1)) yielded double transgenics, most of which became …
We have generated transgenic mice overexpressing TGF-β1 in pancreatic β cells. This resulted in massive fibrosis of the pancreas; in adult mice, most of the acini were replaced by fibrotic and adipose tissues. A conspicuous disorganisation of the islets of Langerhans was also observed, however, the number of β cells was not decreased and the mice were normoglycemic. Backcrossing to transgenic mice overexpressing TNF-α in their islet β cells (which also remain normoglycemic, (1)) yielded double transgenics, most of which became diabetic by the age of 4 months; histological analysis revealed a dramatic decrease in insulin-containing β cells. (Part of this work has been reported in abstract form, Experientia 51, p. A9, February 1995).
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