[PDF][PDF] Ascorbic acid in cancer treatment: let the phoenix fly

N Shenoy, E Creagan, T Witzig, M Levine - Cancer cell, 2018 - cell.com
Cancer cell, 2018cell.com
Vitamin C (ascorbic acid, ascorbate), despite controversy, has re-emerged as a promising
anti-cancer agent. Recent knowledge of intravenous ascorbate pharmacokinetics and
discovery of unexpected mechanisms of ascorbate action have spawned many
investigations. Two mechanisms of anti-cancer activity with ascorbate have gained
prominence: hydrogen peroxide-induced oxidative stress and DNA demethylation mediated
by ten-eleven translocation enzyme activation. Here, we highlight salient aspects of the …
Vitamin C (ascorbic acid, ascorbate), despite controversy, has re-emerged as a promising anti-cancer agent. Recent knowledge of intravenous ascorbate pharmacokinetics and discovery of unexpected mechanisms of ascorbate action have spawned many investigations. Two mechanisms of anti-cancer activity with ascorbate have gained prominence: hydrogen peroxide-induced oxidative stress and DNA demethylation mediated by ten-eleven translocation enzyme activation. Here, we highlight salient aspects of the evolution of ascorbate in cancer treatment, provide insights into the pharmacokinetics of ascorbate, describe mechanisms of its anti-cancer activity in relation to the pharmacokinetics, outline promising preclinical and clinical evidence, and recommend future directions.
cell.com