A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation
TA Dobbs, JA Tainer, SP Lees-Miller - DNA repair, 2010 - Elsevier
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Ku heterodimer
together form the biologically critical DNA-PK complex that plays key roles in the repair of
ionizing radiation-induced DNA double-strand breaks through the non-homologous end-
joining (NHEJ) pathway. Despite elegant and informative electron microscopy studies, the
mechanism by which DNA-PK co-ordinates the initiation of NHEJ has been enigmatic due to
limited structural information. Here, we discuss how the recently described small angle X-ray …
together form the biologically critical DNA-PK complex that plays key roles in the repair of
ionizing radiation-induced DNA double-strand breaks through the non-homologous end-
joining (NHEJ) pathway. Despite elegant and informative electron microscopy studies, the
mechanism by which DNA-PK co-ordinates the initiation of NHEJ has been enigmatic due to
limited structural information. Here, we discuss how the recently described small angle X-ray …