[HTML][HTML] Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1
M Gensler, M Buschbeck, A Ullrich - Journal of Biological Chemistry, 2004 - ASBMB
Signaling by receptor tyrosine kinases (RTK) mediates a variety of complex cellular
functions and in case of deregulation can contribute to pathophysiological processes. A tight
and finely tuned control of RTK activity is therefore critical for the cell. We investigated the
role of the PEST-type protein-tyrosine phosphatase BDP1 in the regulation of HER2, a
member of the epidermal growth factor receptor (EGFR) family of RTKs. Here we
demonstrate that HER2 signaling is highly sensitive to BDP1 activity. Overexpression of …
functions and in case of deregulation can contribute to pathophysiological processes. A tight
and finely tuned control of RTK activity is therefore critical for the cell. We investigated the
role of the PEST-type protein-tyrosine phosphatase BDP1 in the regulation of HER2, a
member of the epidermal growth factor receptor (EGFR) family of RTKs. Here we
demonstrate that HER2 signaling is highly sensitive to BDP1 activity. Overexpression of …