[HTML][HTML] LPA4/p2y9/GPR23 mediates rho-dependent morphological changes in a rat neuronal cell line

K Yanagida, S Ishii, F Hamano, K Noguchi… - Journal of biological …, 2007 - ASBMB
Lysophosphatidic acid (LPA) is a potent lipid mediator that evokes a variety of biological
responses in many cell types via its specific G protein-coupled receptors. In particular, LPA
affects cell morphology, cell survival, and cell cycle progression in neuronal cells. Recently,
we identified p2y 9/GPR23 as a novel fourth LPA receptor, LPA 4 (Noguchi, K., Ishii, S., and
Shimizu, T.(2003) J. Biol. Chem. 278, 25600-25606). To assess the functions of LPA 4 in
neuronal cells, we used rat neuroblastoma B103 cells that lack endogenous responses to …