[HTML][HTML] The fibroblast integrin α11β1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation
S Carracedo, N Lu, SN Popova, R Jonsson… - Journal of Biological …, 2010 - ASBMB
Fibrotic tissue is characterized by an overabundance of myofibroblasts. Thus, understanding
the factors that induce myofibroblast differentiation is paramount to preventing fibrotic
healing. Previous studies have shown that mechanical stress derived from the integrin-
mediated interaction between extracellular matrix and the cytoskeleton promotes
myofibroblast differentiation. Integrin α11β1 is a collagen receptor on fibroblasts. To
determine whether α11β1 can act as a mechanosensor to promote the myofibroblast …
the factors that induce myofibroblast differentiation is paramount to preventing fibrotic
healing. Previous studies have shown that mechanical stress derived from the integrin-
mediated interaction between extracellular matrix and the cytoskeleton promotes
myofibroblast differentiation. Integrin α11β1 is a collagen receptor on fibroblasts. To
determine whether α11β1 can act as a mechanosensor to promote the myofibroblast …