[HTML][HTML] Mast cell restricted mouse and human tryptase· heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by …
A Prieto-García, D Zheng, R Adachi, W Xing… - Journal of Biological …, 2012 - ASBMB
The mouse and human TPSB2 and TPSAB1 genes encode tetramer-forming tryptases
stored in the secretory granules of mast cells (MCs) ionically bound to heparin-containing
serglycin proteoglycans. In mice these genes encode mouse MC protease-6 (mMCP-6) and
mMCP-7. The corresponding human genes encode a family of serine proteases that
collectively are called hTryptase-β. We previously showed that the α chain of fibrinogen is a
preferred substrate of mMCP-7. We now show that this plasma protein also is highly …
stored in the secretory granules of mast cells (MCs) ionically bound to heparin-containing
serglycin proteoglycans. In mice these genes encode mouse MC protease-6 (mMCP-6) and
mMCP-7. The corresponding human genes encode a family of serine proteases that
collectively are called hTryptase-β. We previously showed that the α chain of fibrinogen is a
preferred substrate of mMCP-7. We now show that this plasma protein also is highly …