Nafamostat Mesilate Attenuates Ischemia-Reperfusion–Induced Renal Injury
KR Na, H Choi, JY Jeong, KW Lee, YK Chang… - Transplantation …, 2016 - Elsevier
Background It has been reported that nafamostat mesilate (NM) inhibits inflammatory injury
via inhibition of complement activation in ischemic heart, liver, and intestine. However, it is
unclear if NM also inhibits apoptosis in ischemia-reperfusion (IR)–injured kidney. We
therefore investigated whether NM attenuates IR renal injury that involves inhibition of
apoptosis. Methods HK-2 cells and male C57BL/6 mice were used for this study. C57Bl/6
mice were divided into 4 groups: sham, NM (2 mg/kg)+ sham, IR injury (IR injury; reperfusion …
via inhibition of complement activation in ischemic heart, liver, and intestine. However, it is
unclear if NM also inhibits apoptosis in ischemia-reperfusion (IR)–injured kidney. We
therefore investigated whether NM attenuates IR renal injury that involves inhibition of
apoptosis. Methods HK-2 cells and male C57BL/6 mice were used for this study. C57Bl/6
mice were divided into 4 groups: sham, NM (2 mg/kg)+ sham, IR injury (IR injury; reperfusion …