Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance

A Laatsch, M Merkel, PJ Talmud, T Grewal, U Beisiegel… - Atherosclerosis, 2009 - Elsevier
BACKGROUND: While the role of insulin in glucose uptake and its aberration in diabetes
are well established, the effect of insulin on lipoprotein clearance in the postprandial phase
is not yet fully understood. The dietary lipids are carried in chylomicron remnants (CR) which
are taken up into the liver mainly via LDLR-related protein 1 (LRP1). In this study, the effect
of insulin on LRP1-mediated hepatic CR uptake was investigated. METHODS: The study
was based on determining the subcellular localisation of LRP1 by subcellular fractionation …