[HTML][HTML] Understanding the mechanism of IL-1β secretion
G Lopez-Castejon, D Brough - Cytokine & growth factor reviews, 2011 - Elsevier
The cytokine interleukin-1β (IL-1β) is a key mediator of the inflammatory response. Essential
for the host-response and resistance to pathogens, it also exacerbates damage during
chronic disease and acute tissue injury. It is not surprising therefore that there is a huge level
of interest in how this protein is produced and exported from cells. However, the mechanism
of IL-1β release has proven to be elusive. It does not follow the conventional ER-Golgi route
of secretion. A literature full of disparate observations arising from numerous experimental …
for the host-response and resistance to pathogens, it also exacerbates damage during
chronic disease and acute tissue injury. It is not surprising therefore that there is a huge level
of interest in how this protein is produced and exported from cells. However, the mechanism
of IL-1β release has proven to be elusive. It does not follow the conventional ER-Golgi route
of secretion. A literature full of disparate observations arising from numerous experimental …