Evolution of the transferrin family: conservation of residues associated with iron and anion binding
LA Lambert, H Perri, PJ Halbrooks… - … and Physiology Part B …, 2005 - Elsevier
The transferrin family spans both vertebrates and invertebrates. It includes serum transferrin,
ovotransferrin, lactoferrin, melanotransferrin, inhibitor of carbonic anhydrase, saxiphilin, the
major yolk protein in sea urchins, the crayfish protein, pacifastin, and a protein from green
algae. Most (but not all) contain two domains of around 340 residues, thought to have
evolved from an ancient duplication event. For serum transferrin, ovotransferrin and
lactoferrin each of the duplicated lobes binds one atom of Fe (III) and one carbonate anion …
ovotransferrin, lactoferrin, melanotransferrin, inhibitor of carbonic anhydrase, saxiphilin, the
major yolk protein in sea urchins, the crayfish protein, pacifastin, and a protein from green
algae. Most (but not all) contain two domains of around 340 residues, thought to have
evolved from an ancient duplication event. For serum transferrin, ovotransferrin and
lactoferrin each of the duplicated lobes binds one atom of Fe (III) and one carbonate anion …