Nicotine reduces the levels of surfactant proteins A and D via Wnt/β-catenin and PKC signaling in human airway epithelial cells
W Zou, S Liu, J Hu, Q Sheng, F He, B Li… - Respiratory Physiology & …, 2016 - Elsevier
A deficiency of surfactant proteins A and D has been proposed as a mechanism in airway
remodeling, which is one characteristic of chronic obstructive pulmonary disease (COPD).
We recently showed that in vitro nicotine exposure induces Wnt3a/β-catenin activation,
which is a pathway that has also been implicated in altering levels of SP-A and SP-D.
Nicotine induced activation of protein kinase C (PKC), and the involvement of PKC in
mediating Wnt signaling has been demonstrated previously. The main aim of this study was …
remodeling, which is one characteristic of chronic obstructive pulmonary disease (COPD).
We recently showed that in vitro nicotine exposure induces Wnt3a/β-catenin activation,
which is a pathway that has also been implicated in altering levels of SP-A and SP-D.
Nicotine induced activation of protein kinase C (PKC), and the involvement of PKC in
mediating Wnt signaling has been demonstrated previously. The main aim of this study was …