Utilizing 3D printing technology to merge MRI with histology: a protocol for brain sectioning

NJ Luciano, P Sati, G Nair, JR Guy, SK Ha… - JoVE (Journal of …, 2016 - jove.com
Magnetic resonance imaging (MRI) allows for the delineation between normal and abnormal
tissue on a macroscopic scale, sampling an entire tissue volume three-dimensionally. While
MRI is an extremely sensitive tool for detecting tissue abnormalities, association of signal
changes with an underlying pathological process is usually not straightforward. In the central
nervous system, for example, inflammation, demyelination, axonal damage, gliosis, and
neuronal death may all induce similar findings on MRI. As such, interpretation of MRI scans …