[HTML][HTML] Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family
Lysophosphatidic acid (LPA) is a bioactive lipid mediator with diverse physiological and
pathological actions on many types of cells. LPA has been widely considered to elicit its
biological functions through three types of G protein-coupled receptors, Edg-2 (endothelial
cell differentiation gene-2)/LPA 1/vzg-1 (ventricular zone gene-1), Edg-4/LPA 2, and Edg-
7/LPA 3. We identified an orphan G protein-coupled receptor, p2y 9/GPR23, as the fourth
LPA receptor (LPA 4). Membrane fractions of RH7777 cells transiently expressing p2y …
pathological actions on many types of cells. LPA has been widely considered to elicit its
biological functions through three types of G protein-coupled receptors, Edg-2 (endothelial
cell differentiation gene-2)/LPA 1/vzg-1 (ventricular zone gene-1), Edg-4/LPA 2, and Edg-
7/LPA 3. We identified an orphan G protein-coupled receptor, p2y 9/GPR23, as the fourth
LPA receptor (LPA 4). Membrane fractions of RH7777 cells transiently expressing p2y …