[HTML][HTML] Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex
B Bartkowiak, AL Greenleaf - Journal of Biological Chemistry, 2015 - ASBMB
The coupling of transcription and associated processes has been shown to be dependent
on the RNA polymerase II (RNAPII) C-terminal repeat domain (CTD) and the
phosphorylation of the heptad repeats of which it is composed (consensus sequence Y 1 S 2
P 3 T 4 S 5 P 6 S 7). Two primary S 2 position CTD kinases have been identified in higher
eukaryotes: P-TEFb and CDK12/CyclinK. The more recently discovered CDK12 appears to
act at the 3′-end of the transcription unit and has been identified as a tumor suppressor for …
on the RNA polymerase II (RNAPII) C-terminal repeat domain (CTD) and the
phosphorylation of the heptad repeats of which it is composed (consensus sequence Y 1 S 2
P 3 T 4 S 5 P 6 S 7). Two primary S 2 position CTD kinases have been identified in higher
eukaryotes: P-TEFb and CDK12/CyclinK. The more recently discovered CDK12 appears to
act at the 3′-end of the transcription unit and has been identified as a tumor suppressor for …