Frameshift mutations, neoantigens and tumor-specific CD8+ T cells in microsatellite unstable colorectal cancers
P Maby, J Galon, JB Latouche - Oncoimmunology, 2016 - Taylor & Francis
P Maby, J Galon, JB Latouche
Oncoimmunology, 2016•Taylor & FrancisMicrosatellite unstable colorectal cancers (CRC) express frameshift mutation-derived tumor-
specific neoantigens. We recently showed that:(i) frameshift mutations were correlated with
tumor-infiltrating CD8+ T cell density,(ii) neoantigen-specific cytotoxic T cells could be
obtained in patients whose tumors harbored these mutations, underlining the interest of
developing personalized immunotherapy strategies in these cancers.
specific neoantigens. We recently showed that:(i) frameshift mutations were correlated with
tumor-infiltrating CD8+ T cell density,(ii) neoantigen-specific cytotoxic T cells could be
obtained in patients whose tumors harbored these mutations, underlining the interest of
developing personalized immunotherapy strategies in these cancers.
Abstract
Microsatellite unstable colorectal cancers (CRC) express frameshift mutation-derived tumor-specific neoantigens. We recently showed that: (i) frameshift mutations were correlated with tumor-infiltrating CD8+ T cell density, (ii) neoantigen-specific cytotoxic T cells could be obtained in patients whose tumors harbored these mutations, underlining the interest of developing personalized immunotherapy strategies in these cancers.
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