[HTML][HTML] Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomas
S Inaguma, J Lasota, Z Wang, A Felisiak-Golabek… - Modern Pathology, 2017 - Elsevier
Abstract The CD274 (PD-L1)/PDCD1 (PD-1) pathway is crucial for the modulation of
immune responses and self-tolerance. Aberrantly expressed CD274 allows tumor cells to
evade host immune system and is considered to be a mechanism of adaptive immune
resistance. Inhibition of the CD274/PDCD1 immune checkpoint offers a promising new
therapeutic strategy. Although CD274-expressing tumor cells have been identified in
different types of tumors including colorectal cancer, clinicopathologic profile of these …
immune responses and self-tolerance. Aberrantly expressed CD274 allows tumor cells to
evade host immune system and is considered to be a mechanism of adaptive immune
resistance. Inhibition of the CD274/PDCD1 immune checkpoint offers a promising new
therapeutic strategy. Although CD274-expressing tumor cells have been identified in
different types of tumors including colorectal cancer, clinicopathologic profile of these …