The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

AL Schechter, DF Stern, L Vaidyanathan, SJ Decker… - Nature, 1984 - nature.com
AL Schechter, DF Stern, L Vaidyanathan, SJ Decker, JA Drebin, MI Greene, RA Weinberg
Nature, 1984nature.com
A series of rat neuro/glioblastomas all contain the same transforming gene (neu) which
induces synthesis of a tumour antigen of relative molecular mass (M r) 185,000 (p185). The
neu oncogene bears homology to erb-B and the tumour antigen, p185, is serologically
related to the epidermal growth factor (EGF) receptor. The two proteins, EGF receptor and
p185 appear to be distinct, as they coexist in nontransformed Rat-1 cells.
Abstract
A series of rat neuro/glioblastomas all contain the same transforming gene (neu) which induces synthesis of a tumour antigen of relative molecular mass (Mr) 185,000 (p185). The neu oncogene bears homology to erb-B and the tumour antigen, p185, is serologically related to the epidermal growth factor (EGF) receptor. The two proteins, EGF receptor and p185 appear to be distinct, as they coexist in nontransformed Rat-1 cells.
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