The contribution of nitric oxide and interferon gamma to the regulation of the neuro-inflammation in experimental autoimmune encephalomyelitis

DO Willenborg, M Staykova, S Fordham… - Journal of …, 2007 - Elsevier
Nitric oxide (NO) is a key messenger involved in physiological functions including
endothelium-dependent vascular relaxation, inhibition of platelet adhesion and aggregation
and regulation of inflammatory and immune responses. Here we briefly introduce NO and its
functions and then describe our work over the past several years examining the role of NO in
EAE in both the rat and the mouse. We show that NO plays a significant role in determining
the resistance or susceptibility to EAE in various strains and or sexes of animals. We …