Cell-free oxyhemoglobin in cerebrospinal fluid after aneurysmal subarachnoid hemorrhage: biomarker and potential therapeutic target
M Hugelshofer, CM Sikorski, M Seule, J Deuel… - World neurosurgery, 2018 - Elsevier
M Hugelshofer, CM Sikorski, M Seule, J Deuel, CI Muroi, M Seboek, K Akeret, R Buzzi…
World neurosurgery, 2018•ElsevierBackground Aneurysmal subarachnoid hemorrhage (aSAH) is often complicated by the
occurrence of delayed ischemic neurologic deficits (DIND), which impairs the clinical
outcome of patients. The release of oxyhemoglobin (oxyHb) from lysing erythrocytes into
cerebrospinal fluid (CSF) may critically contribute to the development of DIND. Methods
Ventricular CSF of 18 high-grade (Fisher 3 and 4) aSAH patients was sampled daily from
external ventricular drains between days 0 and 14 after bleeding. CSF was …
occurrence of delayed ischemic neurologic deficits (DIND), which impairs the clinical
outcome of patients. The release of oxyhemoglobin (oxyHb) from lysing erythrocytes into
cerebrospinal fluid (CSF) may critically contribute to the development of DIND. Methods
Ventricular CSF of 18 high-grade (Fisher 3 and 4) aSAH patients was sampled daily from
external ventricular drains between days 0 and 14 after bleeding. CSF was …
Background
Aneurysmal subarachnoid hemorrhage (aSAH) is often complicated by the occurrence of delayed ischemic neurologic deficits (DIND), which impairs the clinical outcome of patients. The release of oxyhemoglobin (oxyHb) from lysing erythrocytes into cerebrospinal fluid (CSF) may critically contribute to the development of DIND.
Methods
Ventricular CSF of 18 high-grade (Fisher 3 and 4) aSAH patients was sampled daily from external ventricular drains between days 0 and 14 after bleeding. CSF was spectrophotometrically analyzed with precise quantification of cell-free oxyHb levels.
Results
OxyHb levels in CSF showed a delayed peak reaching the highest levels in the high-risk period for developing of DIND between days 3 and 14 after aneurysm rupture. Patients with DIND had a significantly higher cumulative oxyHb exposure within the first week after bleeding.
Conclusions
OxyHb levels in CSF may be useful as a biomarker to predict DIND in aSAH patients. The contribution of oxyHb in CSF to the pathogenesis of DIND should be further investigated as a potential therapeutic target.
Elsevier