Transcriptional and post-transcriptional regulation of NK cell development and function
JW Leong, JA Wagner, AR Ireland, TA Fehniger - Clinical Immunology, 2017 - Elsevier
Natural killer (NK) cells are specialized innate lymphoid cells that survey against viral
infections and malignancy. Numerous advances have improved our understanding of the
molecular mechanisms that control NK cell development and function over the past decade.
These include both studies on the regulatory effects of transcription factors and translational
repression via microRNAs. In this review, we summarize our current knowledge of DNA-
binding transcription factors that regulate gene expression and thereby orchestrate NK cell …
infections and malignancy. Numerous advances have improved our understanding of the
molecular mechanisms that control NK cell development and function over the past decade.
These include both studies on the regulatory effects of transcription factors and translational
repression via microRNAs. In this review, we summarize our current knowledge of DNA-
binding transcription factors that regulate gene expression and thereby orchestrate NK cell …