[HTML][HTML] Proteolytic processing of angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on lipoprotein lipase activity
Angiopoietin-like protein 4 (ANGPTL4) has been associated with a variety of diseases. It is
known as an endogenous inhibitor of lipoprotein lipase (LPL), and it modulates lipid
deposition and energy homeostasis. ANGPTL4 is cleaved by unidentified protease (s), and
the biological importance of this cleavage event is not fully understood with respect to its
inhibitory effect on LPL activity. Here, we show that ANGPTL4 appears on the cell surface as
the full-length form, where it can be released by heparin treatment in culture and in vivo …
known as an endogenous inhibitor of lipoprotein lipase (LPL), and it modulates lipid
deposition and energy homeostasis. ANGPTL4 is cleaved by unidentified protease (s), and
the biological importance of this cleavage event is not fully understood with respect to its
inhibitory effect on LPL activity. Here, we show that ANGPTL4 appears on the cell surface as
the full-length form, where it can be released by heparin treatment in culture and in vivo …