Interferon-γ: an overview of signals, mechanisms and functions

K Schroder, PJ Hertzog, T Ravasi… - Journal of Leucocyte …, 2004 - academic.oup.com
Journal of Leucocyte Biology, 2004academic.oup.com
Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current
understanding of IFN-γ ligand, receptor, ignal transduction, and cellular effects with a focus
on macrophage responses and to a lesser extent, responses from other cell types that
influence macrophage function during infection. The current model for IFN-γ signal
transduction is discussed, as well as signal regulation and factors conferring signal …
Abstract
Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes. This article reviews the current understanding of IFN-γ ligand, receptor, ignal transduction, and cellular effects with a focus on macrophage responses and to a lesser extent, responses from other cell types that influence macrophage function during infection. The current model for IFN-γ signal transduction is discussed, as well as signal regulation and factors conferring signal specificity. Cellular effects of IFN-γ are described, including up-regulation of pathogen recognition, antigen processing and presentation, the antiviral state, inhibition of cellular proliferation and effects on apoptosis, activation of microbicidal effector functions, immunomodulation, and leukocyte trafficking. In addition, integration of signaling and response with other cytokines and pathogen-associated molecular patterns, such as tumor necrosis factor-α, interleukin-4, type I IFNs, and lipopolysaccharide are discussed.
Oxford University Press