[HTML][HTML] Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin™ Fab
G Fuh, P Wu, WC Liang, M Ultsch, CV Lee… - Journal of Biological …, 2006 - ASBMB
In the quest to discover new research tools and to develop better agents in the fight against
cancer, two antibodies, G6 and B20-4, were isolated from synthetic antibody phage libraries.
Unlike the AVASTIN™ antibody, a recently approved agent for the treatment of patients with
colorectal cancer, B20-4 and G6 bind and block both human and murine vascular
endothelial growth factor (VEGF). Here we have analyzed and compared the binding
epitopes on VEGF for these three antibodies using alanine-scanning mutagenesis and …
cancer, two antibodies, G6 and B20-4, were isolated from synthetic antibody phage libraries.
Unlike the AVASTIN™ antibody, a recently approved agent for the treatment of patients with
colorectal cancer, B20-4 and G6 bind and block both human and murine vascular
endothelial growth factor (VEGF). Here we have analyzed and compared the binding
epitopes on VEGF for these three antibodies using alanine-scanning mutagenesis and …