IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization
DK Chu, A Llop-Guevara, TD Walker, K Flader… - Journal of Allergy and …, 2013 - Elsevier
BACKGROUND: Allergen exposure at lung and gut mucosae can lead to aberrant TH2
immunity and allergic disease. The epithelium-associated cytokines thymic stromal
lymphopoietin (TSLP), IL-25, and IL-33 are suggested to be important for the initiation of
these responses. OBJECTIVE: We sought to investigate the contributions of TSLP, IL-25,
and IL-33 in the development of allergic disease to the common allergens house dust mite
(HDM) or peanut. METHODS: Neutralizing antibodies or mice deficient in TSLP, IL-25, or IL …
immunity and allergic disease. The epithelium-associated cytokines thymic stromal
lymphopoietin (TSLP), IL-25, and IL-33 are suggested to be important for the initiation of
these responses. OBJECTIVE: We sought to investigate the contributions of TSLP, IL-25,
and IL-33 in the development of allergic disease to the common allergens house dust mite
(HDM) or peanut. METHODS: Neutralizing antibodies or mice deficient in TSLP, IL-25, or IL …