[HTML][HTML] Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion
S Bhatnagar, MS Soni, LS Wrighton, AS Hebert… - Journal of Biological …, 2014 - ASBMB
The abundance and functional activity of proteins involved in the formation of the SNARE
complex are tightly regulated for efficient exocytosis. Tomosyn proteins are negative
regulators of exocytosis. Tomosyn causes an attenuation of insulin secretion by limiting the
formation of the SNARE complex. We hypothesized that glucose-dependent stimulation of
insulin secretion from β-cells must involve reversing the inhibitory action of tomosyn. Here,
we show that glucose increases tomosyn protein turnover. Within 1 h of exposure to 15 mm …
complex are tightly regulated for efficient exocytosis. Tomosyn proteins are negative
regulators of exocytosis. Tomosyn causes an attenuation of insulin secretion by limiting the
formation of the SNARE complex. We hypothesized that glucose-dependent stimulation of
insulin secretion from β-cells must involve reversing the inhibitory action of tomosyn. Here,
we show that glucose increases tomosyn protein turnover. Within 1 h of exposure to 15 mm …