[HTML][HTML] MicroRNAs: genomics, biogenesis, mechanism, and function

DP Bartel - cell, 2004 - cell.com
cell, 2004cell.com
MicroRNAs (miRNAs) are endogenous∼ 22 nt RNAs that can play important regulatory
roles in animals and plants by targeting mRNAs for cleavage or translational repression.
Although they escaped notice until relatively recently, miRNAs comprise one of the more
abundant classes of gene regulatory molecules in multicellular organisms and likely
influence the output of many protein-coding genes.
Abstract
MicroRNAs (miRNAs) are endogenous ∼22 nt RNAs that can play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression. Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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