Urinary tract malformations, obstructive uropathy, and hypoplasia/dysplasia are extremely
important in terms of pediatric health care costs, with end-stage renal failure in children
estimated to cost> $15 billion annually in the United States alone. Even so, little is known
regarding the mechanisms that control these processes. Identified was a unique mutant
mouse model that develops in utero megabladder, resulting in variable
hydroureteronephrosis and chronic renal failure secondary to obstructive uropathy. These …