Experimental short-term fetal bladder outflow obstruction: I. Morphology and cell biology associated with urinary flow impairment
MK Farrugia, DA Long, ML Godley, DM Peebles… - Journal of Pediatric …, 2006 - Elsevier
PURPOSE: In fetal sheep, combined urethral and urachal obstruction initiated at 75 days'
gestation and maintained for 30 days led to dysmorphic bladders, similar to those found in
humans with prune belly syndrome, and uniformly disrupted kidney development. We aimed
to create a less severe model of fetal bladder outlet obstruction, more closely resembling
infants with posterior urethral valves, and additionally to further our understanding on the
role of the urachus. We hypothesized that milder morphological renal tract changes would …
gestation and maintained for 30 days led to dysmorphic bladders, similar to those found in
humans with prune belly syndrome, and uniformly disrupted kidney development. We aimed
to create a less severe model of fetal bladder outlet obstruction, more closely resembling
infants with posterior urethral valves, and additionally to further our understanding on the
role of the urachus. We hypothesized that milder morphological renal tract changes would …