[HTML][HTML] TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase
H Chong-Kopera, K Inoki, Y Li, T Zhu… - Journal of Biological …, 2006 - ASBMB
Tuberous sclerosis complex (TSC) is an autosomal dominant disease characterized by
hamartoma formation in various organs. Two genes responsible for the disease, TSC1 and
TSC2, have been identified. The TSC1 and TSC2 proteins, also called hamartin and tuberin,
respectively, have been shown to regulate cell growth through inhibition of the mammalian
target of rapamycin pathway. TSC1 is known to stabilize TSC2 by forming a complex with
TSC2, which is a GTPase-activating protein for the Rheb small GTPase. We have identified …
hamartoma formation in various organs. Two genes responsible for the disease, TSC1 and
TSC2, have been identified. The TSC1 and TSC2 proteins, also called hamartin and tuberin,
respectively, have been shown to regulate cell growth through inhibition of the mammalian
target of rapamycin pathway. TSC1 is known to stabilize TSC2 by forming a complex with
TSC2, which is a GTPase-activating protein for the Rheb small GTPase. We have identified …