Myeloid derived-suppressor cells: their role in cancer and obesity
S Ostrand-Rosenberg - Current opinion in immunology, 2018 - Elsevier
Current opinion in immunology, 2018•Elsevier
Highlights•MDSC promote tumor growth by blocking antitumor immunity and cancer
immunotherapies.•Obesity promotes tumor growth by inducing the accumulation of
MDSC.•MDSC protect against some of the metabolic dysfunction associated with
obesity.•MDSC accumulation and function are driven by leptin and fatty acid
metabolism.Myeloid-derived suppressor cells (MDSC) are present in most individuals with
cancer where they inhibit adaptive and innate antitumor immunity and are an obstacle to …
immunotherapies.•Obesity promotes tumor growth by inducing the accumulation of
MDSC.•MDSC protect against some of the metabolic dysfunction associated with
obesity.•MDSC accumulation and function are driven by leptin and fatty acid
metabolism.Myeloid-derived suppressor cells (MDSC) are present in most individuals with
cancer where they inhibit adaptive and innate antitumor immunity and are an obstacle to …
Highlights
- MDSC promote tumor growth by blocking antitumor immunity and cancer immunotherapies.
- Obesity promotes tumor growth by inducing the accumulation of MDSC.
- MDSC protect against some of the metabolic dysfunction associated with obesity.
- MDSC accumulation and function are driven by leptin and fatty acid metabolism.
Myeloid-derived suppressor cells (MDSC) are present in most individuals with cancer where they inhibit adaptive and innate antitumor immunity and are an obstacle to cancer immunotherapies. Chronic inflammation is characteristic of adipose tissue and is a risk factor for the onset and progression of cancer in obese individuals. Because MDSC accumulate in response to inflammation, it has been hypothesized that one of the mechanisms by which obesity promotes malignancy is through the induction of MDSC. This article reviews the data supporting this hypothesis, the role of leptin and fatty acid metabolism in the induction of MDSC, and the surprising finding that although MDSC promote tumor progression, they are protective against some of the metabolic dysfunction associated with obesity.
Elsevier