Hereditary pancreatitis and mutation of the trypsinogen gene
P Weber, V Keim, KP Zimmer - Archives of disease in childhood, 1999 - adc.bmj.com
P Weber, V Keim, KP Zimmer
Archives of disease in childhood, 1999•adc.bmj.comHereditary pancreatitis is a rare form of chronic recurrent pancreatitis. A family, in which 11
members had chronic pancreatitis, five had diabetes, and two had pancreatic cancer, was
studied, and hereditary pancreatitis was diagnosed in all patients by demonstrating the
mutation in exon 3 of the cationic trypsinogen gene (R117H). The clinical implications of
genotypic analysis in hereditary pancreatitis are discussed.
members had chronic pancreatitis, five had diabetes, and two had pancreatic cancer, was
studied, and hereditary pancreatitis was diagnosed in all patients by demonstrating the
mutation in exon 3 of the cationic trypsinogen gene (R117H). The clinical implications of
genotypic analysis in hereditary pancreatitis are discussed.
Hereditary pancreatitis is a rare form of chronic recurrent pancreatitis. A family, in which 11 members had chronic pancreatitis, five had diabetes, and two had pancreatic cancer, was studied, and hereditary pancreatitis was diagnosed in all patients by demonstrating the mutation in exon 3 of the cationic trypsinogen gene (R117H). The clinical implications of genotypic analysis in hereditary pancreatitis are discussed.
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