Protease inhibitors in acute pancreatitis: lessons from the bench and failed clinical trials
VP Singh, ST Chari - Gastroenterology, 2005 - gastrojournal.org
Despite strong experimental evidence (Gastroenterology 1989; 96: 193–199, J Med Invest
2004; 51: 186–193, J Clin Invest 1986; 78: 1056–1063) and more than 70 clinical trials
performed over the past 40 years (JAMA 1963; 183: 52–55), there is no clear-cut proof that
protease inhibitors (PI) alter the clinical course of acute pancreatitis (AP). As knowledge of
AP has evolved, a look back at most of these clinical trials reveals that they suffered from
conceptual, design, and methodological problems, making their application to current …
2004; 51: 186–193, J Clin Invest 1986; 78: 1056–1063) and more than 70 clinical trials
performed over the past 40 years (JAMA 1963; 183: 52–55), there is no clear-cut proof that
protease inhibitors (PI) alter the clinical course of acute pancreatitis (AP). As knowledge of
AP has evolved, a look back at most of these clinical trials reveals that they suffered from
conceptual, design, and methodological problems, making their application to current …