Protein structure modeling with MODELLER
B Webb, A Sali - Functional genomics: Methods and protocols, 2017 - Springer
B Webb, A Sali
Functional genomics: Methods and protocols, 2017•SpringerGenome sequencing projects have resulted in a rapid increase in the number of known
protein sequences. In contrast, only about one-hundredth of these sequences have been
characterized at atomic resolution using experimental structure determination methods.
Computational protein structure modeling techniques have the potential to bridge this
sequence-structure gap. In the following chapter, we present an example that illustrates the
use of MODELLER to construct a comparative model for a protein with unknown structure …
protein sequences. In contrast, only about one-hundredth of these sequences have been
characterized at atomic resolution using experimental structure determination methods.
Computational protein structure modeling techniques have the potential to bridge this
sequence-structure gap. In the following chapter, we present an example that illustrates the
use of MODELLER to construct a comparative model for a protein with unknown structure …
Abstract
Genome sequencing projects have resulted in a rapid increase in the number of known protein sequences. In contrast, only about one-hundredth of these sequences have been characterized at atomic resolution using experimental structure determination methods. Computational protein structure modeling techniques have the potential to bridge this sequence-structure gap. In the following chapter, we present an example that illustrates the use of MODELLER to construct a comparative model for a protein with unknown structure. Automation of a similar protocol has resulted in models of useful accuracy for domains in more than half of all known protein sequences.
Springer