Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system
R Ciccocioppo, D Economidou, R Rimondini… - Biological …, 2007 - Elsevier
BACKGROUND: Activation of the NOP receptor by its endogenous ligand
nociceptin/orphanin FQ reduces ethanol intake in genetically selected alcohol preferring
Marchigian Sardinian alcohol preferring (msP) rats. Here we evaluated whether
buprenorphine, a partial agonist at μ-opioid and NOP receptors, would reduce ethanol
consumption in msP rats via activation of NOP receptors. METHODS: Marchigian Sardinian
alcohol preferring rats trained to drink 10% alcohol 2 hours/day were injected with …
nociceptin/orphanin FQ reduces ethanol intake in genetically selected alcohol preferring
Marchigian Sardinian alcohol preferring (msP) rats. Here we evaluated whether
buprenorphine, a partial agonist at μ-opioid and NOP receptors, would reduce ethanol
consumption in msP rats via activation of NOP receptors. METHODS: Marchigian Sardinian
alcohol preferring rats trained to drink 10% alcohol 2 hours/day were injected with …