The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis
T Miyata, J Takeda, Y Iida, N Yamada, N Inoue… - Science, 1993 - science.org
T Miyata, J Takeda, Y Iida, N Yamada, N Inoue, M Takahashi, K Maeda, T Kitani, T Kinoshita
Science, 1993•science.orgThe glycosylphosphatidylinositol (GPI) anchor is a membrane attachment structure of many
proteins and occurs in a wide variety of eukaryotes from yeasts to mammals. The structure of
the core of the GPI anchor is conserved in protozoa and mammals and so is its biosynthetic
pathway. A complementary DNA encoding a human protein termed PIG-A
(phosphatidylinositol glycan-class A) was cloned. PIG-A was necessary for synthesis of N-
acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor …
proteins and occurs in a wide variety of eukaryotes from yeasts to mammals. The structure of
the core of the GPI anchor is conserved in protozoa and mammals and so is its biosynthetic
pathway. A complementary DNA encoding a human protein termed PIG-A
(phosphatidylinositol glycan-class A) was cloned. PIG-A was necessary for synthesis of N-
acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor …
The glycosylphosphatidylinositol (GPI) anchor is a membrane attachment structure of many proteins and occurs in a wide variety of eukaryotes from yeasts to mammals. The structure of the core of the GPI anchor is conserved in protozoa and mammals and so is its biosynthetic pathway. A complementary DNA encoding a human protein termed PIG-A (phosphatidylinositol glycan-class A) was cloned. PIG-A was necessary for synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.
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