One-pot synthesis of tetrasubstituted pyrazoles—proof of regiochemistry
U Hanefeld, CW Rees, AJP White… - Journal of the Chemical …, 1996 - pubs.rsc.org
U Hanefeld, CW Rees, AJP White, DJ Williams
Journal of the Chemical Society, Perkin Transactions 1, 1996•pubs.rsc.org1-Alkyl-5-amino-3-aryl-4-cyanopyrazoles, useful intermediates for fused heterocyclic
systems, are synthesised by a one-pot three-step procedure from acid chlorides,
malononitrile and alkylhydrazines. The regiochemistry of the hydrazine incorporation was
proved in each case by X-ray crystallography and NMR spectroscopy.
systems, are synthesised by a one-pot three-step procedure from acid chlorides,
malononitrile and alkylhydrazines. The regiochemistry of the hydrazine incorporation was
proved in each case by X-ray crystallography and NMR spectroscopy.
1-Alkyl-5-amino-3-aryl-4-cyanopyrazoles, useful intermediates for fused heterocyclic systems, are synthesised by a one-pot three-step procedure from acid chlorides, malononitrile and alkylhydrazines. The regiochemistry of the hydrazine incorporation was proved in each case by X-ray crystallography and NMR spectroscopy.
The Royal Society of Chemistry