[HTML][HTML] Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury
N Hanawa, M Shinohara, B Saberi, WA Gaarde… - Journal of Biological …, 2008 - ASBMB
Previously, we demonstrated JNK plays a central role in acetaminophen (APAP)-induced
liver injury (Gunawan, BK, Liu, ZX, Han, D., Hanawa, N., Gaarde, WA, and Kaplowitz,
N.(2006) Gastroenterology 131, 165–178). In this study, we examine the mechanism
involved in activating JNK and explore the downstream targets of JNK important in
promoting APAP-induced liver injury in vivo. JNK inhibitor (SP600125) was observed to
significantly protect against APAP-induced liver injury. Increased mitochondria-derived …
liver injury (Gunawan, BK, Liu, ZX, Han, D., Hanawa, N., Gaarde, WA, and Kaplowitz,
N.(2006) Gastroenterology 131, 165–178). In this study, we examine the mechanism
involved in activating JNK and explore the downstream targets of JNK important in
promoting APAP-induced liver injury in vivo. JNK inhibitor (SP600125) was observed to
significantly protect against APAP-induced liver injury. Increased mitochondria-derived …