[HTML][HTML] The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein

X Xu, Y Shi, W Gao, G Mao, G Zhao, S Agrawal… - Journal of Biological …, 2002 - ASBMB
Recent studies have suggested a possible role for presenilin proteins in apoptotic cell death
observed in Alzheimer's disease. The mechanism by which presenilin proteins regulate
apoptotic cell death is not well understood. Using the yeast two-hybrid system, we previously
isolated a novel protein, presenilin-associated protein (PSAP) that specifically interacts with
the C terminus of presenilin 1 (PS1), but not presenilin 2 (PS2). Here we report that PSAP is
a mitochondrial resident protein sharing homology with mitochondrial carrier protein. PSAP …