[HTML][HTML] Cellular FLICE-like inhibitory protein (c-FLIP) and PS1-associated protein (PSAP) mediate presenilin 1-induced γ-secretase-dependent and-independent …
L Zeng, C Hu, F Zhang, DC Xu, MZ Cui, X Xu - Journal of Biological …, 2015 - ASBMB
Presenilin 1 (PS1) has been implicated in apoptosis; however, its mechanism remains
elusive. We report that PS1-induced apoptosis was associated with cellular FLICE-like
inhibitory protein (c-FLIP) turnover and that γ-secretase inhibitor blocked c-FLIP turnover
and also partially blocked PS1-induced apoptosis. A complete inhibition of PS1-induced
apoptosis was achieved by knockdown of PS1-associated protein (PSAP), a mitochondrial
proapoptotic protein that forms a complex with Bax upon induction of apoptosis, in the …
elusive. We report that PS1-induced apoptosis was associated with cellular FLICE-like
inhibitory protein (c-FLIP) turnover and that γ-secretase inhibitor blocked c-FLIP turnover
and also partially blocked PS1-induced apoptosis. A complete inhibition of PS1-induced
apoptosis was achieved by knockdown of PS1-associated protein (PSAP), a mitochondrial
proapoptotic protein that forms a complex with Bax upon induction of apoptosis, in the …